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Amazingly, the physical body already provides tPA in the lining of blood vessels to greatly help dissolve clots; the d-dimer tests searches for the breakdown products of that effort. MCG researchers, led by Dr. Robinson, wondered if indeed they could improve the performance of clot detection by giving small amounts of tPA prior to the test. They hypothesized that the low part of the legs has lower prices of clot dissolution because a clot large more than enough to occlude a vessel in the leg would minimize get in touch with between your clot and the blood. Using pigs as their pet model, the researchers initial performed d-dimer studies to obtain a baseline, triggered a clot in the femoral vein in the groin then. An hour later, there were no significant changes in the d-dimer amounts even though, if the organic clot-busters were operating as might be expected, the levels should rapidly have risen.